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Ogretmen, Besim
One or more keywords matched the following properties of Ogretmen, Besim
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keywords Molecular mechanisms of the regulation of telomerase and telomeres by ceramide signaling
keywords Mechanisms of ceramide-mediated regulation of PP2A by lipid-protein interactions
keywords Regulation of ER stress and apoptosis by sphingolipid metabolism
overview Dr. Ogretmen’s research is focused on deciphering the regulation and function of bioactive sphingolipids, specifically ceramide and sphingosine-1-phosphate (S1P), in cancer development/progression and therapy. Specifically, roles and mechanisms of action of ceramide, an emerging tumor suppressor lipid which induces antiproliferative and apoptotic responses, are investigated. Some of the ongoing projects include: 1) determining mechanisms of the regulation of telomerase activity by sphingolipid metabolism and signaling; 2) exploring ceramide/ lipid-mediated regulation of te lomere length; 3) investigating the mechanisms of the activation of protein phosphatase 2A (PP2A) through controlling the function of its biological inhibitor I2PP2A/ SET oncoprotein by FTY720 (Fingolimod); and 4) determining the roles and mechanisms of the regulation of de novo ceramide synthesis by ceramide synthases in ER stress, apoptosis, autophagy/mitophagy, and/or necroptosis in lung and head and neck cancers using cell culture, animal, and clinical cancer models. In addition, tumor-promoting roles of S1P, including the induction of cancer progression, promotion of metastasis, and development of drug resistance in various cancer models including human leukemias, are explored. The long-term goal of these studies is to develop mechanism-based therapeutic strategies against human cancers. Positions: Professor, Department of Biochemistry and Molecular Biology Principal Investigator and Director, Center of Biomedical Research Excellence in Lipidomics and Pathobiology Program Leader, Lipid Signaling in Cancer Program, Hollings Cancer Center, Medical University of South Carolina Director, Lipidomics Shared Resource, Hollings Cancer Center, Medical University of South Carolina
One or more keywords matched the following items that are connected to Ogretmen, Besim
Item TypeName
Academic Article Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region.
Academic Article Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide.
Academic Article Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.
Academic Article Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells.
Academic Article Molecular mechanisms of ceramide-mediated telomerase inhibition in the A549 human lung adenocarcinoma cell line.
Academic Article Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.
Academic Article PERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.
Academic Article Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant.
Academic Article Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.
Academic Article Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.
Academic Article Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
Academic Article Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.
Academic Article Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function.
Academic Article Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling.
Academic Article Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.
Academic Article Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.
Concept Up-Regulation
Concept Gene Expression Regulation
Concept Down-Regulation
Concept Gene Expression Regulation, Viral
Concept Gene Expression Regulation, Enzymologic
Concept Allosteric Regulation
Concept Gene Expression Regulation, Neoplastic
Academic Article Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.
Academic Article Sphingosine kinase-2 maintains viral latency and survival for KSHV-infected endothelial cells.
Academic Article Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.
Academic Article Regulation of PP2A by Sphingolipid Metabolism and Signaling.
Academic Article Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer.
Academic Article Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.
Academic Article Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity.
Academic Article The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy.
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